• LogD/Solubility

  Aqueous Solubility

• Permeability
  Caco-2

  Uni or Bidirectional

• Permeability
  MDR1-MDCK

  BBB and P-gp

• Permeability
  CellPort Pgp

  P-gp and BCRP

• Metabolic Stability

  Human or Rat Liver
  Microsomes

• Protein Binding

  Human or Rat Plasma
   

• Pharmacokinetics

  Exposure and Bioavailability

• ADME Express Sales Order

  and Sample Submittal Form

  In Vitro OS021

  In Vivo OS022

Please contact us for shipping instructions and necessary forms to ensure a more efficient order process.

Please note the following:

• A minimum of 5 assays must be ordered. This requirement may be met by either running five different assays on one compound or running five compounds through one assay.
• These prices are for test compounds received in DMSO. An additional $25.00 will be charged for each test compound that is sent in powder form, except for the EA104 Solubility assay.
• The assay results are issued in a Basic Report format. An example of a Basic Report can be download from the list below. For an additional fee the results can be issued in a Standard Report format.

*Please note the following for in vivo assays:

• These prices are per compound for a minimum of two compounds in a single order. This requirement may be met by either individual or cassette dosing.
• The price for cassette dosing is applicable only if one analytical method and one single injection can be used for the determination of all test compounds.
• One hour formulation prep cost has been included in the study price. Additional time required for formulation preparation will be charged at $200.00 per hour.
• The timeline for these studies is ten (10) business days from protocol signoff and test compound receipt, except for the dog exposure assay.

The Essential ADME Express assays are screening assays useful for identifying promising drug-like leads from among the hits in your HTS screening libraries.

Why use an Express Assay?

• Because you will receive your assay results in less than 10 working days (turnaround is 10 days or less)
• Because the assay protocols are based on our experience in handling thousands of individual compounds year after year
• Because our reputation is based on producing the highest quality data
• Because the express permeability assays (EA201, EA202) use the same validated cell line that are used to generate data used in submissions to the FDA to support BCS biowaivers
• Because the Express P-gp assay (EA203) use the highly characterized cell-based model with controlled P-gp protein expression and passage number criteria to ensure that the levels of P-gp are understood at the time of the experiment

Why Rely on Absorption Systems for early ADME Assessment?

Absorption Systems Express Assays provide reproducible data year after year. The Express assays enable companies to profile the ADME properties of their compounds with the confidence, knowing that the test systems are under control. Providing high quality, consistent and reproducible data is our business.

A description of these assays can be found in the Assay Data Sheets listed in the Related Literature section below. Click on the ones you want to download.

We also offer a custom version for each of these assay. Desciptions of these assays can be found beginning on our Custom Assay page.