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In Life Only —dose and sample non-human primates, dogs, mini-pigs and rodents
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LogP, LogD Determination
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Metabolic Stability determined using hepatocytes, intestinal microsomes, intestinal homogenates, liver microsomes, or S9 fractions
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Metabolite Identification
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Metabolite Profiling
- Ocular Permeability
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Permeability through Caco-2, MDCK, MDR1-MDCK cell monolayers
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Permeability through excised buccal, dermal, nasal, or vaginal tissue
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Permeability through excised human or rat intestinal mucosa
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Permeability through rat intestine using an in situ intestinal model
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P-gp Substrate and Inhibitor Determination
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PK Analysis
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pKa Determination
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Plasma Protein Binding
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Preclinical Formulation Assessment
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Site Specific Absorption Models —ported or cannulated bile duct, portal vein, intestinal segments in dogs, mini-pigs, and rodents
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Solubility
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UGT Phenotyping
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UGT Inhibition
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