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Safety Suite™
Safety Suite™ is the name we use for our entire package of in vitro drug safety assays, to identify compounds with the potential for:
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Metabolism-based drug-drug interactions
- Metabolic stability
- CYP reaction phenotyping
- CYP induction
- CYP inhibition
- Metabolite identification
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Transporter-based drug-drug interactions
- P-gp (ABCB1) substrates, inhibitors, and inducers
- BCRP (ABCG2) substrates and inhibitors
Absorption Systems can do any or all of these studies with parent compound and/or metabolites. We can identify metabolites in various species and generate semi-preparative quantities of oxidative metabolites biomimetically for characterization in one or more of the Safety Suite assays.
Related Literature
This assay is used to determine if a test compound is a human P-gp substrate by measuring its bidirectional permeability across MDR1-MDCK and MDCK cell monolayers in the presence and absence of P-gp inhibitors.
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This assay is used to determine if a test compound is a P-gp inhibitor by measuring its effect on the bidirectional permeability of the P-gp substrate, digoxin, through MDR1-MDCK or Caco-2 cell monolayers.
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This assay is used to determine the percent remaining and half-life of a test compound incubated with liver microsomes in the presence and absence of NADPH.
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This assay is used to determine the percent remaining and half-life of a test compound incubated with S9 fraction in the presence and absence of cofactors.
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This assay is used to determine the percent remaining and half-life of a test compound incubated with either cryopreserved or fresh hepatocytes.
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This assay is used to screen for inhibition of cytochrome P450 (CYP) enzymes by a test compound.
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Cytochrome P450 reaction phenotyping using CYP-specific Supersomes™
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This assay is used to assess the potential of a test compound to induce CYP1A2, CYP2B6, and CYP3A4 in fresh or cryopreserved human hepatocytes.
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This assay is used to determine the percent remaining and half-life of a test compound incubated with human intestinal microsomes in the presence and absence of NADPH.
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This assay is used to determine the potency with which a test compound inhibits cytochrome P450 (CYP) enzymes.
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This assay is used to determine whether a test compound is a mechanism-based inhibitor of cytochrome P450 (CYP) enzymes.
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Brochures
A comprehensive package of in vitro drug-drug interaction and other safety-related tests
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