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Literature
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Case Study
- CS100 - In vitro studies, the FDA-endorsed shortcut
- CS101 - Safety First and Fast
- CS102 - Increasing Specificity in Transporter Assays
Essential ADME
- EA101 - Solubility Determined by Shake-Flask Assay Data Sheet
- EA102 - LogD by Shake-Flask Assay Data Sheet
- EA103 - pKa, LogP, and LogD By Potentiometric Titration Assay Data Sheet
- EA104 - Express Solubility Assay Data Sheet
- EA105 - Express LogD by Shake-Flask Assay Data Sheet
- EA150 - Stability in Gastric Fluids Assay Data Sheet
- EA151 - Stability in Plasma Assay Data Sheet
- EA181 - Cell Cytotoxicity Assay Data Sheet
- EA182 - Hepatocyte Cytotoxicity Assay Data Sheet
- EA190 - Hemolysis
- EA201 - Express Unidirectional Permeability Through Caco-2 Monolayers Assay Data Sheet
- EA201r - Example of a Basic Report Unidirectional Caco-2
- EA202 - Express Bidirectional Permeability Through Caco-2 Monolayers Assay Data Sheet
- EA202r - Example of a Basic Report Bidirectional Caco-2 assay
- EA203 - Express MDR1-MDCK for BBB Penetration Potential Assay Data Sheet
- EA204 - Express P-gp Substrate Assessment Determined Using MDR1-MDCK Cell Monolayers Assay Data Sheet
- EA205 - Unidirectional Permeability Through Intestinal Tissue Assay Data Sheet
- EA206 - Bidirectional Permeability Through Intestinal Tissue Assay Data Sheet
- EA207 - Unidirectional Permeability Through Porcine Buccal Epithelium Assay Data Sheet
- EA208 - Unidirectional Permeability Through Porcine Nasal Epithelium Assay Data Sheet
- EA209 - Unidirectional Permeability Through Excised Skin Assay Data Sheet
- EA211 - Unidirectional Permeability Through Caco-2 Cell Monolayers Assay Data Sheet
- EA212 - Bidirectional Permeability Through Caco-2 Cell Monolayers Assay Data Sheet
- EA212r - Example of a Standard Report for a Bidirectional Caco-2 Assay
- EA218 - Human P-gp Substrate Assessment Across MDR1-MDCK Cell Monolayers
- EA219 - P-gp Inhibitor Assessment Across Cell Monolayers
- EA250 - Express P-gp Substrate Assessment in CellPort CPT-B1 BCRP Knockdown Cells
- EA251 - Express BCRP Substrate Assessment in CPT-B1 BCRP Knockdown Cells
- EA401 - Express Metabolic Stability (human liver microsomes) Assay Data Sheet
- EA402 - Express Metabolic Stability (rat liver microsomes) Assay Data Sheet
- EA403 - Metabolic Stability in Liver Microsomes Assay Data Sheet
- EA403r - Example of a Standard Report for a Metabolic Stability Assay
- EA404 - Metabolic Stability in the Presence of S9 Fractions Assay Data Sheet
- EA405 - Metabolic Stability in the Presence of Hepatocytes Assay Data Sheet
- EA406 - IC50 Determination Using Fluorogenic Substrates Assay Data Sheet
- EA407 - CYP Inhibition Screen in Human Liver Microsomes Using LC-MS-MS Assay Data Sheet
- EA408 - CYP 450 Phenotyping Using Supersomes Assay Data Sheet
- EA409 - Induction of CYP1A2, 2C9, and 3A4 in Human Hepatocytes Assay Data Sheet
- EA410 - Ki Determination in Human Liver Microsomes Using LC-MS-MS Assay Data Sheet
- EA411 - Metabolic Stability in Human Intestinal Microsomes Assay Data Sheet
- EA412 - Metabolite Identification (Microsomal or S9) Assay Data Sheet
- EA413 - CYP Inhibition IC50 Using LC-MS-MS in Human Liver Microsomes
- EA414 - Mechanism-based CYP Inhibition Using LC-MS-MS in Human Liver Microsomes
- EA470r - Example of a Basic Report for Metabolism and Protein Binding Assays
- EA701 - Express Plasma Protein Binding (human plasma) Assay Data Sheet
- EA702 - Express Plasma Protein Binding (rat plasma) Assay Data Sheet
- EA703 - Plasma Protein Binding Using Ultracentrifugation Assay Data Sheet
- EA703r - Example of a Standard Report for a Human Plasma Protein Binding Assay
- EA704 - Plasma Protein Binding Using Equilibrium Dialysis Assay Data Sheet
- EA705 - Plasma Protein Binding Using Ultrafiltration Assay Data Sheet
- EA707 - Express Fraction Unbound (rat brain)
- EA801 - Relative Bioavailability in Rats Assay Data Sheet
- EA802 - Test Compound Brain to Plasma Ratio in Rat Assay Data Sheet
- EA803 - Rat Brain Perfusion Assay Data Sheet
- EA804 - Absolute Bioavailability in Mice Assay Data Sheet
- EA805 - Bioavailability in Dogs Assay Data Sheet
- EA807 - Express Bioavailability-Exposure in Mice Assay Data Sheet
- EA808 - Express Bioavailability-Exposure in Rats Assay Data Sheet
- EA810 - Express Bioavailability-Exposure in Dogs Assay Data Sheet
- EA811 - Rat Carotid Infusion
- EA812 - Express Bioavailability-Exposure in Dogs Non-crossover
- EA901 - Preliminary BCS Solubility Classification by Shake Flask Assay Data Sheet
- EA902 - GLP BCS Solubility Classification by Shake Flask Assay Data Sheet
- EA903 - Preliminary BCS Permeability Classification Using Caco-2 Cell Monolayers Assay Data Sheet
- EA904 - GLP BCS Permeability Classification Using Caco-2 Cell Monolayers Assay Data Sheet
Overview Sheet
- OS001 - FDA Drug Interaction Guidance Sept 2006
- OS010 - Index of Assays and Services
- OS011 - Specialized ADME Assessment
- OS021 - ADME Express In Vitro Sales Order and Sample Submittal form
- OS022 - ADME Express In Vivo Sales Order and Sample Submittal form
- OS109 - Formulation Assessment Primer
- OS200b - Overview of Absorption Systems' Blood-brain Barrier Models
- OS400b - Overview of Absorption Systems' Rat Biliary Excretion Model
- OS600a - Overview of Absorption Systems' Bioanalytical Services
Poster Presentation
- PP1 - Functional Evidence of Multiple Efflux Transport Systems in Caco-2 Cell Model
- PP2 - Utility of the Pgp Knockout Mouse In Situ Brain Perfusion to Determine the Brain Penetration Potential of Pgp Substrate Drugs
- PP3 - Silencing of Breast Cancer Resistance Protein Expression by Lentiviral shRNA transduction particles in Caco-2 models
- PP4 - Metabolizing_Activities_in_Rabbit_Cornea_and_Conjunctiva
- PP5 - Evaluation of a New Proprietary GRAS Formulation for Oral and Intravenous Administration
- PP6 - Functional Characterization of the MRP2 Transporter Using the Isolated Rat Liver Perfusion Model
- PP7 - Silencing of Breast Cancer Resistance Protein (BCRP) Expression and Function in Caco-2 Cells Using Lentiviral shRNA-mediated RNA Interference
- PP8 - Functional characterization of RNAi induced BCRP knockdown Caco-2 cells
- PP9 - Evaluation of the effect of 4-aromatic substitution on metabolic stability and metabolite profiles of 2AT using in vitro and ex-vivo models
- PP10 - Silencing of Multidrug Resistance-associated Protein 2 (MRP-2) Expression and Function in Caco-2 cells using Lentiviral shRNA
- PP11 - Pharmacokinetic Evaluation of Tizanidine Oral Spray in Male Beagle Dogs: Presented by Novadel
- PP12 - Characterization of Excised Rabbit Cornea and Conjunctiva as In Vitro Models for Ocular Drug Absorption Studies
- PP13 - Differentiation of Reversible and Mechanism-Based Inhibitors of Human CYP Mediated-Reactions by an IC50 Shift Approach
- PP14 - Hydrolysis of Latanoprost in Rabbit Ocular Tissues
- PP15 - Investigation of transporters involved in biliary clearance of drugs in the human liver using Caco-2 cells with stable MDR1 and MRP2 knockdown by shRNA: Presented by AstraZeneca
- PP16 - A comparison of the in vitro hydrolysis of Oseltamivir in matrices from various species
Research Report
- RR1 - Induction of CYP 1A and 3A4 Human Hepatocytes
- RR2 - New Assay for Determining the Barriers to Bioavailability
- RR3 - Induction of Cytochrome P450- 2C9- 2C19 and 2B6 Activities in Cryopreserve Human Hepatocytes
- RR6 - Establishment of an Intraduodenal Fistula Dog Model for Biopharmaceutics Studies
- RR7 - Intestinal Access Port Dog Model for Gastrointestinal Site for Drug Absorption
- RR9 - Identification of Cytochrome P450 Isoforms Responsible for Canadine Metabolism Using Human Supersomes
- RR10 - Ocular Summary Report
- RR11 - Superior Pgp Assay System
- RR13 - Evaluation of the MDR-MDCK cell line as a permeability screen for the blood brain barrier