Glossary Terms

Absorption • Accuracy • ADME • Agonist • Al • Allometric Scaling • Ampholyte • Antagonist • Apparent Permeability • ASLP • Assay

Barriers to Bioavailability • Basic Report • Bioanalysis • Bioavailability • Biological Matrix • Biopharmaceutics • biowaiver • Blood-Brain Barrier • Bolus Dosing • Buffer

Caco-2 • Calcein AM • Calibration Standards • Cannula • Cell Based Assay • Clearance • Cross Validation • Custom Assay • Custom Report Format • CYP

Detection Limit • Distribution • DMPK • Drug

Effective Permeability • Effectiveness • Efflux • Enterohepatic Recirculation • Excretion

FDA • Fluorescence

Gavage • Good Laboratory Practices

Half Life • Hit • Hydrophilic • Hydrophobic • Hygroscopicity

IACUC • In Silico • In Situ • In Situ Brain Perfusion • In Vitro • In Vivo • Internal Standard • Investigational New Drug

LC/MS/MS • Lead Optimization • Leg • Limits of Quantification • Linearity • Lipophilic • LLOQ • Log D • Log P

MDR protein • MDR1-MDCK • Membrane Transport Proteins • Metabolism • Molecular Weight

P-gp Inhibitor • Partial Validation • Patent • Peroral • Pgp • Pharmacodynamics • Pharmacokinetics • Pharmacology • pKa • PO • Polymorphs • Potency • Precision • Preclinical • Predictive ADME • Process Efficiency • Prodrug

Range • Raw Data • Reaction Phenotyping • Recovery • Regional Absorption • Renal Clearance • Repeatability • Reproducibility • Robustness • Ruggedness

S9 • Selectivity • Sensitivity • Solid Phase Extraction • Specificity • Sponsor • Stability • Standard Report • Stereoisomers (R or S) • Sublingual • Substrate

Test Article • Test Compound • Tolerability • Tolerance Specification for a Formulation

validated cell line • Validation • Vehicle • Volume of Distribution